Michigan vs. Indiana prediction, odds, line: 2022 Week 6 college football picks, best bets from proven model

No. 4 Michigan (5-0) travels to Memorial Stadium to square off against Indiana in a Big Ten battle on Saturday afternoon. The Wolverines have dominated this series, leading 60-10 all-time. In 2021, Michigan defeated the Hoosiers 29-7. Indiana hopes to end its two-game skid and gain a valuable victory within the conference.

Kickoff in Bloomington is set for noon ET. The Wolverines are -22.5 in the latest Michigan vs. Indiana odds from Caesars Sportsbook. The over/under for total points is set at 59. Before making any Indiana vs. Michigan picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,100 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Michigan vs. Indiana and just locked in its picks and CFB predictions. You can head to SportsLine to see its picks. Now, here are several college football odds and betting lines for Indiana vs. Michigan:

  • Michigan vs. Indiana spread: Michigan -22.5
  • Michigan vs. Indiana over/under: 59 points
  • Michigan vs. Indiana money line: Michigan -1200, Indiana +750
  • MICH: The Wolverines are 4-0 ATS in their last four road games
  • IND: Over is 9-1 in Hoosiers’ last 10 home games vs. a team with a winning road record
  • Michigan vs. Indiana picks: See picks at SportsLine

Featured Game | Indiana Hoosiers vs. Michigan Wolverines

Why Michigan can cover

The Wolverines have been playing outstanding on defense. They aren’t allowing teams to get into much of a rhythm against them, consistently getting after the quarterback. Michigan has totaled 15 sacks this far. This unit is fourth in the Big Ten in scoring (11.6), third in total yards allowed per game (252), third in passing yards allowed (157.8) and fifth in rushing yards allowed (94.2).

Sophomore linebacker Junior Colson is an athletic playmaker who runs sideline to sideline. Colson is a force in the run game with the quickness to defend tight ends and running backs. He’s leading the team in total tackles with 37. Linebacker Mike Morris has been doing damage off the edge. The Florida native leads the team in TFLs (6), sacks (4) and QB hits (3).

Why Indiana can cover

Senior linebacker Cam Jones is constantly all over the field for this squad. Jones is light on his feet with a superb change of direction ability. The Tennessee native owns good closing speed with long arms to wrap up ball carriers. He’s 10th in the nation in total tackles (54) including 24 solo. Jones has tallied double-digit stops in three straight games.

Freshman linebacker Dasan McCullough is having a terrific start to his college career. McCullough has long arms that allow him to extend into the chest and arms of defenders, constantly shedding blocks. The Indiana native is first on the team in sacks (4) with 19 total tackles and 4.5 TFLs.

How to make Indiana vs. Michigan picks

SportsLine’s model is leaning Under on the total. It also says one side of the spread hits in 60% of simulations. You can only see the model’s CFB picks here.

So who wins Michigan vs. Indiana? And which side of the spread hits in 60% of simulations? Visit SportsLine now to see which side of the spread you need to jump on, all from the model that has crushed its college football picks, and find out.